Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images
Identifieur interne : 000132 ( Main/Exploration ); précédent : 000131; suivant : 000133Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images
Auteurs : Yiannis S. Chatzizisis [Grèce] ; Vassilis G. Koutkias [Grèce] ; Konstantinos Toutouzas [Grèce] ; Andreas Giannopoulos [Grèce] ; Ioanna Chouvarda [Grèce] ; Maria Riga [Grèce] ; Antonios P. Antoniadis [Grèce] ; Grigorios Cheimariotis [Grèce] ; Charalampos Doulaverakis [Grèce] ; Ioannis Tsampoulatidis [Grèce] ; Konstantina Bouki [Grèce] ; Ioannis Kompatsiaris [Grèce] ; Christodoulos Stefanadis [Grèce] ; Nicos Maglaveras [Grèce] ; George D. Giannoglou [Grèce]Source :
- International journal of cardiology [ 0167-5273 ] ; 2014.
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Abstract
Objectives: The analysis of intracoronary optical coherence tomography (OCT) images is based on manual identification of the lumen contours and relevant structures. However, manual image segmentation is a cumbersome and time-consuming process, subject to significant intra- and inter-observer variability. This study aims to present and validate a fully-automated method for segmentation of intracoronary ocr images. Methods: We studied 20 coronary arteries (mean length = 39.7 ± 10.0 mm) from 20 patients who underwent a clinically-indicated cardiac catheterization. The OCT images (n = 1812) were segmented manually, as well as with a fully-automated approach. A semi-automated variation of the fully-automated algorithm was also applied. Using certain lumen size and lumen shape characteristics, the fully- and semi-automated segmentation algorithms were validated over manual segmentation, which was considered as the gold standard. Results: Linear regression and Bland-Altman analysis demonstrated that both the fully-automated and semi-automated segmentation had a very high agreement with the manual segmentation, with the semi-automated approach being slightly more accurate than the fully-automated method. The fully-automated and semi-automated OCT segmentation reduced the analysis time by more than 97% and 86%, respectively, compared to manual segmentation. Conclusions: In the current work we validated a fully-automated OCT segmentation algorithm, as well as a semi-automated variation of it in an extensive "real-life" dataset of OCT images. The study showed that our algorithm can perform rapid and reliable segmentation of OCT images.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images</title><author><name sortKey="Chatzizisis, Yiannis S" sort="Chatzizisis, Yiannis S" uniqKey="Chatzizisis Y" first="Yiannis S." last="Chatzizisis">Yiannis S. Chatzizisis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cardiovascular Engineering and Atherosclerosis Laboratory, First Department of Cardiology, AHEPA University Hospital. Aristotle University Medical School</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Koutkias, Vassilis G" sort="Koutkias, Vassilis G" uniqKey="Koutkias V" first="Vassilis G." last="Koutkias">Vassilis G. Koutkias</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratory of Medical Informatics, Aristotle University Medical School</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Toutouzas, Konstantinos" sort="Toutouzas, Konstantinos" uniqKey="Toutouzas K" first="Konstantinos" last="Toutouzas">Konstantinos Toutouzas</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>First Department of Cardiology, Hippokration Hospital, Athens University Medical School</s1><s2>Athens</s2><s3>GRC</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Giannopoulos, Andreas" sort="Giannopoulos, Andreas" uniqKey="Giannopoulos A" first="Andreas" last="Giannopoulos">Andreas Giannopoulos</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cardiovascular Engineering and Atherosclerosis Laboratory, First Department of Cardiology, AHEPA University Hospital. Aristotle University Medical School</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Chouvarda, Ioanna" sort="Chouvarda, Ioanna" uniqKey="Chouvarda I" first="Ioanna" last="Chouvarda">Ioanna Chouvarda</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratory of Medical Informatics, Aristotle University Medical School</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Riga, Maria" sort="Riga, Maria" uniqKey="Riga M" first="Maria" last="Riga">Maria Riga</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>First Department of Cardiology, Hippokration Hospital, Athens University Medical School</s1><s2>Athens</s2><s3>GRC</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Antoniadis, Antonios P" sort="Antoniadis, Antonios P" uniqKey="Antoniadis A" first="Antonios P." last="Antoniadis">Antonios P. Antoniadis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cardiovascular Engineering and Atherosclerosis Laboratory, First Department of Cardiology, AHEPA University Hospital. Aristotle University Medical School</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Cheimariotis, Grigorios" sort="Cheimariotis, Grigorios" uniqKey="Cheimariotis G" first="Grigorios" last="Cheimariotis">Grigorios Cheimariotis</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratory of Medical Informatics, Aristotle University Medical School</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Doulaverakis, Charalampos" sort="Doulaverakis, Charalampos" uniqKey="Doulaverakis C" first="Charalampos" last="Doulaverakis">Charalampos Doulaverakis</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Information Technologies Institute, Centre for Research and Technology Hellas</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Tsampoulatidis, Ioannis" sort="Tsampoulatidis, Ioannis" uniqKey="Tsampoulatidis I" first="Ioannis" last="Tsampoulatidis">Ioannis Tsampoulatidis</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Information Technologies Institute, Centre for Research and Technology Hellas</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Bouki, Konstantina" sort="Bouki, Konstantina" uniqKey="Bouki K" first="Konstantina" last="Bouki">Konstantina Bouki</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Second Department of Cardiology, General Hospital of Nikaia</s1><s2>Piraeus</s2><s3>GRC</s3><sZ>11 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Piraeus</wicri:noRegion></affiliation></author><author><name sortKey="Kompatsiaris, Ioannis" sort="Kompatsiaris, Ioannis" uniqKey="Kompatsiaris I" first="Ioannis" last="Kompatsiaris">Ioannis Kompatsiaris</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Information Technologies Institute, Centre for Research and Technology Hellas</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Stefanadis, Christodoulos" sort="Stefanadis, Christodoulos" uniqKey="Stefanadis C" first="Christodoulos" last="Stefanadis">Christodoulos Stefanadis</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>First Department of Cardiology, Hippokration Hospital, Athens University Medical School</s1><s2>Athens</s2><s3>GRC</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Maglaveras, Nicos" sort="Maglaveras, Nicos" uniqKey="Maglaveras N" first="Nicos" last="Maglaveras">Nicos Maglaveras</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratory of Medical Informatics, Aristotle University Medical School</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Giannoglou, George D" sort="Giannoglou, George D" uniqKey="Giannoglou G" first="George D." last="Giannoglou">George D. Giannoglou</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cardiovascular Engineering and Atherosclerosis Laboratory, First Department of Cardiology, AHEPA University Hospital. Aristotle University Medical School</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">14-0101693</idno><date when="2014">2014</date><idno type="stanalyst">PASCAL 14-0101693 INIST</idno><idno type="RBID">Pascal:14-0101693</idno><idno type="wicri:Area/PascalFrancis/Corpus">000022</idno><idno type="wicri:Area/PascalFrancis/Curation">000742</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000015</idno><idno type="wicri:doubleKey">0167-5273:2014:Chatzizisis Y:clinical:validation:of</idno><idno type="wicri:Area/Main/Merge">000133</idno><idno type="wicri:Area/Main/Curation">000132</idno><idno type="wicri:Area/Main/Exploration">000132</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images</title><author><name sortKey="Chatzizisis, Yiannis S" sort="Chatzizisis, Yiannis S" uniqKey="Chatzizisis Y" first="Yiannis S." last="Chatzizisis">Yiannis S. Chatzizisis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cardiovascular Engineering and Atherosclerosis Laboratory, First Department of Cardiology, AHEPA University Hospital. Aristotle University Medical School</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Koutkias, Vassilis G" sort="Koutkias, Vassilis G" uniqKey="Koutkias V" first="Vassilis G." last="Koutkias">Vassilis G. Koutkias</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratory of Medical Informatics, Aristotle University Medical School</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Toutouzas, Konstantinos" sort="Toutouzas, Konstantinos" uniqKey="Toutouzas K" first="Konstantinos" last="Toutouzas">Konstantinos Toutouzas</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>First Department of Cardiology, Hippokration Hospital, Athens University Medical School</s1><s2>Athens</s2><s3>GRC</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Giannopoulos, Andreas" sort="Giannopoulos, Andreas" uniqKey="Giannopoulos A" first="Andreas" last="Giannopoulos">Andreas Giannopoulos</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cardiovascular Engineering and Atherosclerosis Laboratory, First Department of Cardiology, AHEPA University Hospital. Aristotle University Medical School</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Chouvarda, Ioanna" sort="Chouvarda, Ioanna" uniqKey="Chouvarda I" first="Ioanna" last="Chouvarda">Ioanna Chouvarda</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratory of Medical Informatics, Aristotle University Medical School</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Riga, Maria" sort="Riga, Maria" uniqKey="Riga M" first="Maria" last="Riga">Maria Riga</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>First Department of Cardiology, Hippokration Hospital, Athens University Medical School</s1><s2>Athens</s2><s3>GRC</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Antoniadis, Antonios P" sort="Antoniadis, Antonios P" uniqKey="Antoniadis A" first="Antonios P." last="Antoniadis">Antonios P. Antoniadis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cardiovascular Engineering and Atherosclerosis Laboratory, First Department of Cardiology, AHEPA University Hospital. Aristotle University Medical School</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Cheimariotis, Grigorios" sort="Cheimariotis, Grigorios" uniqKey="Cheimariotis G" first="Grigorios" last="Cheimariotis">Grigorios Cheimariotis</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratory of Medical Informatics, Aristotle University Medical School</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Doulaverakis, Charalampos" sort="Doulaverakis, Charalampos" uniqKey="Doulaverakis C" first="Charalampos" last="Doulaverakis">Charalampos Doulaverakis</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Information Technologies Institute, Centre for Research and Technology Hellas</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Tsampoulatidis, Ioannis" sort="Tsampoulatidis, Ioannis" uniqKey="Tsampoulatidis I" first="Ioannis" last="Tsampoulatidis">Ioannis Tsampoulatidis</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Information Technologies Institute, Centre for Research and Technology Hellas</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Bouki, Konstantina" sort="Bouki, Konstantina" uniqKey="Bouki K" first="Konstantina" last="Bouki">Konstantina Bouki</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Second Department of Cardiology, General Hospital of Nikaia</s1><s2>Piraeus</s2><s3>GRC</s3><sZ>11 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Piraeus</wicri:noRegion></affiliation></author><author><name sortKey="Kompatsiaris, Ioannis" sort="Kompatsiaris, Ioannis" uniqKey="Kompatsiaris I" first="Ioannis" last="Kompatsiaris">Ioannis Kompatsiaris</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Information Technologies Institute, Centre for Research and Technology Hellas</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Stefanadis, Christodoulos" sort="Stefanadis, Christodoulos" uniqKey="Stefanadis C" first="Christodoulos" last="Stefanadis">Christodoulos Stefanadis</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>First Department of Cardiology, Hippokration Hospital, Athens University Medical School</s1><s2>Athens</s2><s3>GRC</s3><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Maglaveras, Nicos" sort="Maglaveras, Nicos" uniqKey="Maglaveras N" first="Nicos" last="Maglaveras">Nicos Maglaveras</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratory of Medical Informatics, Aristotle University Medical School</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Giannoglou, George D" sort="Giannoglou, George D" uniqKey="Giannoglou G" first="George D." last="Giannoglou">George D. Giannoglou</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cardiovascular Engineering and Atherosclerosis Laboratory, First Department of Cardiology, AHEPA University Hospital. Aristotle University Medical School</s1><s2>Thessaloniki</s2><s3>GRC</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Grèce</country><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">International journal of cardiology</title><title level="j" type="abbreviated">Int. j. cardiol.</title><idno type="ISSN">0167-5273</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">International journal of cardiology</title><title level="j" type="abbreviated">Int. j. cardiol.</title><idno type="ISSN">0167-5273</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algorithm</term><term>Cardiology</term><term>Cardiovascular disease</term><term>Comparative study</term><term>Coronary artery</term><term>Decision tree</term><term>Image processing</term><term>Method study</term><term>Optical coherence tomography</term><term>Segmentation</term><term>Test validation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie de l'appareil circulatoire</term><term>Validation test</term><term>Algorithme</term><term>Arbre décision</term><term>Traitement image</term><term>Segmentation</term><term>Artère coronaire</term><term>Tomographie en cohérence optique</term><term>Etude méthode</term><term>Etude comparative</term><term>Cardiologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives: The analysis of intracoronary optical coherence tomography (OCT) images is based on manual identification of the lumen contours and relevant structures. However, manual image segmentation is a cumbersome and time-consuming process, subject to significant intra- and inter-observer variability. This study aims to present and validate a fully-automated method for segmentation of intracoronary ocr images. Methods: We studied 20 coronary arteries (mean length = 39.7 ± 10.0 mm) from 20 patients who underwent a clinically-indicated cardiac catheterization. The OCT images (n = 1812) were segmented manually, as well as with a fully-automated approach. A semi-automated variation of the fully-automated algorithm was also applied. Using certain lumen size and lumen shape characteristics, the fully- and semi-automated segmentation algorithms were validated over manual segmentation, which was considered as the gold standard. Results: Linear regression and Bland-Altman analysis demonstrated that both the fully-automated and semi-automated segmentation had a very high agreement with the manual segmentation, with the semi-automated approach being slightly more accurate than the fully-automated method. The fully-automated and semi-automated OCT segmentation reduced the analysis time by more than 97% and 86%, respectively, compared to manual segmentation. Conclusions: In the current work we validated a fully-automated OCT segmentation algorithm, as well as a semi-automated variation of it in an extensive "real-life" dataset of OCT images. The study showed that our algorithm can perform rapid and reliable segmentation of OCT images.</div></front></TEI><affiliations><list><country><li>Grèce</li></country></list><tree><country name="Grèce"><noRegion><name sortKey="Chatzizisis, Yiannis S" sort="Chatzizisis, Yiannis S" uniqKey="Chatzizisis Y" first="Yiannis S." last="Chatzizisis">Yiannis S. Chatzizisis</name></noRegion><name sortKey="Antoniadis, Antonios P" sort="Antoniadis, Antonios P" uniqKey="Antoniadis A" first="Antonios P." last="Antoniadis">Antonios P. Antoniadis</name><name sortKey="Bouki, Konstantina" sort="Bouki, Konstantina" uniqKey="Bouki K" first="Konstantina" last="Bouki">Konstantina Bouki</name><name sortKey="Cheimariotis, Grigorios" sort="Cheimariotis, Grigorios" uniqKey="Cheimariotis G" first="Grigorios" last="Cheimariotis">Grigorios Cheimariotis</name><name sortKey="Chouvarda, Ioanna" sort="Chouvarda, Ioanna" uniqKey="Chouvarda I" first="Ioanna" last="Chouvarda">Ioanna Chouvarda</name><name sortKey="Doulaverakis, Charalampos" sort="Doulaverakis, Charalampos" uniqKey="Doulaverakis C" first="Charalampos" last="Doulaverakis">Charalampos Doulaverakis</name><name sortKey="Giannoglou, George D" sort="Giannoglou, George D" uniqKey="Giannoglou G" first="George D." last="Giannoglou">George D. Giannoglou</name><name sortKey="Giannopoulos, Andreas" sort="Giannopoulos, Andreas" uniqKey="Giannopoulos A" first="Andreas" last="Giannopoulos">Andreas Giannopoulos</name><name sortKey="Kompatsiaris, Ioannis" sort="Kompatsiaris, Ioannis" uniqKey="Kompatsiaris I" first="Ioannis" last="Kompatsiaris">Ioannis Kompatsiaris</name><name sortKey="Koutkias, Vassilis G" sort="Koutkias, Vassilis G" uniqKey="Koutkias V" first="Vassilis G." last="Koutkias">Vassilis G. Koutkias</name><name sortKey="Maglaveras, Nicos" sort="Maglaveras, Nicos" uniqKey="Maglaveras N" first="Nicos" last="Maglaveras">Nicos Maglaveras</name><name sortKey="Riga, Maria" sort="Riga, Maria" uniqKey="Riga M" first="Maria" last="Riga">Maria Riga</name><name sortKey="Stefanadis, Christodoulos" sort="Stefanadis, Christodoulos" uniqKey="Stefanadis C" first="Christodoulos" last="Stefanadis">Christodoulos Stefanadis</name><name sortKey="Toutouzas, Konstantinos" sort="Toutouzas, Konstantinos" uniqKey="Toutouzas K" first="Konstantinos" last="Toutouzas">Konstantinos Toutouzas</name><name sortKey="Tsampoulatidis, Ioannis" sort="Tsampoulatidis, Ioannis" uniqKey="Tsampoulatidis I" first="Ioannis" last="Tsampoulatidis">Ioannis Tsampoulatidis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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